Otherwise your profile will not be updated. Here don’t forget to click on Save Profile option. Then confirm your newly changed password. Edit email information its name and add new one. You will be given by the option to edit business email information as preferred. Open the side menu by pressing the three dots in the top-left side. This study opens up a new possibility for MI treatment with immunoregulatory and antifibrotic injectable polysaccharide-based hydrogel.First of all you need log in to Spotify for Artists app. The outcomes at 28 days post-surgery indicate efficient restoration of cardiac functions and attenuation of cardiac fibrosis. The acute MI models are established and the infarcted male rats are treated with this injectable OFu-Lipo-VP-PGA hydrogel after MI. Then an injectable hydrogel (termed as OFu-Lipo-VP-PGA) is formed through addition reaction between the aldehyde groups of OFu-Lipo-VP and the thiol groups of thiol-modified poly(γ-glutamic acid) (PGA-SH), where the thiol groups can also aid in eliminating ROS. The coated fucoidan itself acts as a reactive oxygen species (ROS) scavenger and inflammation regulator, thus facilitating angiogenesis function by eliciting endogenous vascular endothelial growth factor secretion of macrophages. To this end, cationic liposomes loading YAP inhibitor verteporfin (Lipo-VP) is prepared and coated with oxidized fucoidan (OFu), a unique anti-inflammation polysaccharide, to form anti-fibrotic and immunoregulatory nanodrug (OFu-Lipo-VP). Herein, a yes-associated protein (YAP)-suppressive nanodrug-crosslinked self-immunoregulatory polysaccharide injectable hydrogel is fabricated for the first time.
The cardiac fibrosis caused by excessive deposition of collagen and the fibro-inflammatory cascade reaction severely impedes the cardiac regenerative efficiency after myocardial infarction (MI) so that the onefold treating target is far from satisfying therapeutic efficacy.
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